Trends in Psychiatry and Psychotherapy
Trends in Psychiatry and Psychotherapy
Review Article

The impact of inflammatory and metabolic markers on depression, anxiety, and cognition after COVID-19: A narrative review

Elton Jorge Bessa Diniz, Fulvio Alexandre Scorza, Fabrício Maués Santos Rodrigues, Claudia Berlim de Mello, Tatiana Carvalho de Souza Bonetti, Karina Ramalho Bortoluci, Jair de Jesus Mari

Downloads: 2
Views: 589


There has been growing concern about the long-term effects of COVID-19 on mental health. The biological factors common to psychiatric conditions and COVID-19 are not yet fully understood.

We narratively reviewed prospective longitudinal studies that measured metabolic or inflammatory markers and assessed psychiatric sequalae and cognitive impairment in individuals with COVID-19 at least 3 months after the infection. A literature search identified three relevant cohort studies.

Overall, depressive symptomatology and cognitive deficits persisted for up to one year after COVID-19; depression and cognitive changes were predicted by acute inflammatory markers, and changes in these markers correlated with changes in depressive symptomatology; female sex, obesity, and the presence of inflammatory markers were associated with more severe clusters of physical and mental health status in patients’ self-perceived recovery; and plasma metabolic profiles of patients continued to differ from those of healthy controls three months after hospital discharge, which were associated with widespread alterations in neuroimaging, reflecting issues with white matter integrity. This is a non-systematic review and cautions should be made while interpreting the conclusions.

In individuals affected by the COVID-19, prolonged exposure to stress and alterations in metabolic and inflammatory markers plays a central role in psychiatric sequalae and cognitive deficits in the long term.


COVID-19; Inflammation; Metabolomics; Depression; Anxiety; Cognitive Impairment.

Submitted date:

Accepted date:

6499c0dfa95395107c702593 trends Articles
Links & Downloads

Trends Psychiatry Psychother

Share this page
Page Sections